Potency Syzygium cumini L as adjuvant therapy on mice model malaria
The objective of the study was to prove the potential extract of <em>Syzygium cumini</em> L leaf and stem bark as an adjuvant to malaria modelling mice. Antimalarial effects were assessed by the percentage of parasitemia, growth inhibition, 50% dose level (ED50), Parasite Clearance Time...
| Main Authors: | , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
University of Mosul, College of Veterinary Medicine
2018-06-01
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| Series: | Iraqi Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://vetmedmosul.com/article_153801_25cdaac12a973423f0cbaf5f46e61046.pdf |
| Summary: | The objective of the study was to prove the potential extract of <em>Syzygium cumini</em> L leaf and stem bark as an adjuvant to malaria modelling mice. Antimalarial effects were assessed by the percentage of parasitemia, growth inhibition, 50% dose level (ED50), Parasite Clearance Time (PCT), Recrudescence Time (RT) of Plasmodium berghei. Male albino Swiss mice infected with 1x10<sup>5</sup> <em>P. berghei</em> parasite in 0.2 ml intraperitoneally. Treatment with chloroquine 25 mg/kg body weight, chloroquine combination 25 mg/kg body weight with leaf and stem bark extract of <em>Syzygium cumini</em> L dose 600 mg / kg body weight for 4 days and 24 hours after infection, and then its activity as antimalarial and adjuvant therapy were observed. The results showed that the extract of <em>Syzygium</em> <em>cumini</em> L leaf combined with chloroquine gives highly significant result in inhibiting the growth of parasites than the chloroquine alone and the extract of <em>Syzygium cumini</em> L leaf combined with chloroquine gives the Parasite Clearance Time faster and Recrudescence Time (RT) longer than the other treatment. |
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| ISSN: | 1607-3894 2071-1255 |