Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients
Background and purpose — Currently, no clear evidence exists on the pattern of use of antithrombotics at admission in hip fracture patients and how this has changed over time. We investigated temporal trends in—and factors associated with—the use of antithrombotics in patients admitted with a fractu...
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2016-07-01
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Online Access: | http://dx.doi.org/10.1080/17453674.2016.1195662 |
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doaj-88d52ec166a54e008150abbff9fd23802021-03-02T10:18:24ZengTaylor & Francis GroupActa Orthopaedica1745-36741745-36822016-07-0187436837310.1080/17453674.2016.11956621195662Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patientsChristian Medom Madsen0Christopher Jantzen1Jes Bruun Lauritzen2Bo Abrahamsen3Henrik L Jorgensen4Bispebjerg Hospital, University of CopenhagenBispebjerg Hospital, University of CopenhagenBispebjerg Hospital, University of CopenhagenHolbæk HospitalBispebjerg Hospital, University of CopenhagenBackground and purpose — Currently, no clear evidence exists on the pattern of use of antithrombotics at admission in hip fracture patients and how this has changed over time. We investigated temporal trends in—and factors associated with—the use of antithrombotics in patients admitted with a fractured hip. Patients and methods — This was a population-based cohort study including all patients aged 18 years or above who were admitted with a hip fracture in Denmark from 1996 to 2012. The Danish national registries were used to collect information on medication use, vital status, and comorbidity. Results — From 1996 to 2012, the proportion of patients using antithrombotics in general increased by a factor of 2.3 from 19% to 43% (p < 0.001). More specifically, the use of anticoagulants increased by a factor of 6.8 and the use of antiplatelets increased by a factor of 2.1. When we adjusted for possible confounders, the use of antithrombotics still increased for every calendar year (relative risk (RR) = 1.03, CI: 1.03–1.04; p < 0.001). Age, sex, and Charlson comorbidity index were all associated with the use of antithrombotics (all p < 0.001). Interpretation — The proportion of hip fracture patients using antithrombotics at admission has increased substantially in Denmark over the last 2 decades. This highlights the need for evidence-based guidelines on how to handle patients using antithrombotics to ensure safe surgery and to avoid surgical delay.http://dx.doi.org/10.1080/17453674.2016.1195662 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christian Medom Madsen Christopher Jantzen Jes Bruun Lauritzen Bo Abrahamsen Henrik L Jorgensen |
spellingShingle |
Christian Medom Madsen Christopher Jantzen Jes Bruun Lauritzen Bo Abrahamsen Henrik L Jorgensen Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients Acta Orthopaedica |
author_facet |
Christian Medom Madsen Christopher Jantzen Jes Bruun Lauritzen Bo Abrahamsen Henrik L Jorgensen |
author_sort |
Christian Medom Madsen |
title |
Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients |
title_short |
Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients |
title_full |
Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients |
title_fullStr |
Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients |
title_full_unstemmed |
Temporal trends in the use of antithrombotics at admission: A nationwide population-based cohort study of 154,047 hip fracture patients |
title_sort |
temporal trends in the use of antithrombotics at admission: a nationwide population-based cohort study of 154,047 hip fracture patients |
publisher |
Taylor & Francis Group |
series |
Acta Orthopaedica |
issn |
1745-3674 1745-3682 |
publishDate |
2016-07-01 |
description |
Background and purpose — Currently, no clear evidence exists on the pattern of use of antithrombotics at admission in hip fracture patients and how this has changed over time. We investigated temporal trends in—and factors associated with—the use of antithrombotics in patients admitted with a fractured hip. Patients and methods — This was a population-based cohort study including all patients aged 18 years or above who were admitted with a hip fracture in Denmark from 1996 to 2012. The Danish national registries were used to collect information on medication use, vital status, and comorbidity. Results — From 1996 to 2012, the proportion of patients using antithrombotics in general increased by a factor of 2.3 from 19% to 43% (p < 0.001). More specifically, the use of anticoagulants increased by a factor of 6.8 and the use of antiplatelets increased by a factor of 2.1. When we adjusted for possible confounders, the use of antithrombotics still increased for every calendar year (relative risk (RR) = 1.03, CI: 1.03–1.04; p < 0.001). Age, sex, and Charlson comorbidity index were all associated with the use of antithrombotics (all p < 0.001). Interpretation — The proportion of hip fracture patients using antithrombotics at admission has increased substantially in Denmark over the last 2 decades. This highlights the need for evidence-based guidelines on how to handle patients using antithrombotics to ensure safe surgery and to avoid surgical delay. |
url |
http://dx.doi.org/10.1080/17453674.2016.1195662 |
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