Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients

Pharmacokinetic/pharmacodynamic relationships of FTY720 in kidney transplant recipients

FTY720 is a new and effective immunosuppressive agent, which produces peripheral blood lymphopenia through a lymphocyte homing effect. We investigated the relationship between the dose of FTY720 or blood concentration (pharmacokinetics, PK) and peripheral lymphopenia (pharmacodynamics, PD) in 23 kid...

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Bibliographic Details
Main Authors: S.I. Park, C.R. Felipe, P.G. Machado, R. Garcia, A. Skerjanec, R. Schmouder, H. Tedesco-Silva Jr., J.O. Medina-Pestana
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2005-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
FTY720
Lymphopenia
Pharmacokinetics
Pharmacodynamics
Immunosuppression
Renal transplants
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500005

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