The Expression of MicroRNA-155 (miR-155) and Carcinoembryonic Antigen Messenger RNA (CEA mRNA) in Peripheral Blood of Patients with Oral Squamous Cell Carcinomas (OSCC)

• Main Authors: Armita Narimani, Farzaneh Hosseini, Naghmeh Bahrami, Abdolreza Mohamadnia
• Format: Article
• Language: fas
• Published: Vesnu Publications 2019-03-01
• Series: مجله دانشکده پزشکی اصفهان
• Subjects: Head and neck squamous cell carcinoma; Early diagnosis; MicroRNAs; Carcinoembryonic antigen; mRNA
• Online Access: http://jims.mui.ac.ir/index.php/jims/article/view/10925

Background: Oral squamous cell carcinoma (OSCC) accounts for about 90% of all malignant oral tumors, and is often diagnosed in advanced stages. In this study, changes in the expression of microRNA-155 (miR-155) and carcinoembryonic antigen messenger RNA (CEA mRNA) in peripheral blood of patients with oral cancer were investigated. Methods: In this study, 30 patients and 30 healthy people were selected. The miR-155 and CEA mRNA levels in their peripheral blood were measured and evaluated using real-time polymerase chain reaction (real-time PCR) technique. Findings: Positive miR-155 marker was observed in 21 people from 30 with oral cancer, and 7 of 30 healthy subjects. The CEA mRNA marker was positive in 23 of the 30 patients, and 5 out of 30 healthy subjects. Conclusion: In sum, the outcome of this study can be seen as a screening diagnostic test for early detection of the disease in the early stages.