Protective Effects of ALDH1A Enzyme Inhibition on <i>Helicobacter</i>-Induced Colitis in Smad3<sup>−/−</sup> Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells

Protective Effects of ALDH1A Enzyme Inhibition on <i>Helicobacter</i>-Induced Colitis in Smad3<sup>−/−</sup> Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells

Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α...

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Bibliographic Details
Main Authors: Audrey Seamons, Michael Haenisch, Stacey Meeker, Olesya Pershutkina, Thea Brabb, Piper M. Treuting, Jisun Paik
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Nutrients
Subjects:
retinoic acid
ALDH1A enzymes
immunity
inflammatory bowel disease
mouse model
Online Access:https://www.mdpi.com/2072-6643/12/10/2927

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