Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model

Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model

Context The uric acid metabolism pathway is more similar in primates and humans than in rodents. However, there are no reports of using primates to establish animal models of hyperuricaemia (HUA). Objectives To establish an animal model highly related to HUA in humans. Materials and methods Inosine...

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Bibliographic Details
Main Authors: Dong-hong Tang, Chen-yun Wang, Xi Huang, Hong-kun Yi, Zhe-li Li, Kai-li Ma, You-song Ye, Jian-wen Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
inosine
uric acid
hyperuricaemia
animal model
Online Access:http://dx.doi.org/10.1080/13880209.2020.1871373

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