Study of serum Ceruloplasmin, Malondialdehyde (MDA) and hs-CRP as biomarkers of severity in Psoriasis

• Main Author: 1. K Prashanth, Assistant Professor, Department of Biochemistry, Rajiv Gandhi Institute of Medical Sciences [RIMS], Adilabad, Telangana State, India. 2. MohdInayatulla Khan, Assistant Professor, Department of Physiology, Rajiv Gandhi Institute of Medical Sciences [RIMS], Adilabad, Telangana State, India.
• Format: Article
• Language: English
• Published: Prathima Institute of Medical Sciences 2020-12-01
• Series: Perspectives In Medical Research
• Subjects: serum ceruloplasmin; malondialdehyde (mda); hs-crp; psoriasis area and severity index; pasi
• Online Access: https://www.pimr.org.in/2020-vol8-issue-3/originalarticle13_v1.pdf

Background : Psoriasis is one of the common diseases diagnosed in dermatology clinics. It is characterized by erythematous and sharply demarcated papules covered by silvery micaceous scales. Although, etiology is an unclear genetic predisposition seen in 50% of cases. This study aimed to determine the role of malondialdehyde (MDA), ceruloplasmin, and C-Reactive Protein (hs-CRP) as markers of severity of the disease. Methods: N= 75 patients were selected and divided into three categories of different severity based on PASI scores. Those with PASI score of < 10 were mild cases included in group I and with PASI Scores of 11-15 were moderate cases included in group II and PASI scores >15 were in group III. N=25 age and sex-matched taken from healthy people were included in group IV controls. Results: correlation coefficient (r) values were calculated between PASI and biomarkers. Of the biomarkers, a strong positive correlation was shown by serum ceruloplasmin levels in group I and group II (r = + 0.9). Ironically the values in group III of ceruloplasmin were positive the correlation was not strong. The Malondialdehyde values in group III also showed a strong positive correlation with r values of + 0.93. In the hsCRP group, a strong positive correlation was found in group III however, a weak positive correlation was found in group I and group II. Materials and Methods: A Hospital-based Prospective study was conducted in the Department of Medicine, Santhiram medical college & general hospital for a 2 year period.Universal Sampling Technique was used for the selection of study subjects.The study population included patients admitted with fever, flank pain, and positive urine or blood cultures in the department of general medicine in Santhiram medical college and general hospital.The final sample size was 50 subjects. Conclusion: Serum ceruloplasmin was positively correlated with PASI scores and serum MDA levels were highly correlated in severe cases of psoriasis. The hs-CRP was also found to be elevated in the psoriasis cases as compared to controls however, a significant positive correlation was found in severe cases. Therefore, psoriasis severity can be monitored by estimating the biomarkers, especially in severe cases.