Large-Scale Domain Motions and Pyridoxal-5'-Phosphate Assisted Radical Catalysis in Coenzyme B12-Dependent Aminomutases

Large-Scale Domain Motions and Pyridoxal-5'-Phosphate Assisted Radical Catalysis in Coenzyme B12-Dependent Aminomutases

Lysine 5,6-aminomutase (5,6-LAM) and ornithine 4,5-aminomutase (4,5-OAM) are two of the rare enzymes that use assistance of two vitamins as cofactors. These enzymes employ radical generating capability of coenzyme B12 (5'-deoxyadenosylcobalamin, dAdoCbl) and ability of pyridoxal-5'-phospha...

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Bibliographic Details
Main Authors: Amarendra Nath Maity, Yung-Han Chen, Shyue-Chu Ke
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
coenzyme B12 (5'-deoxyadenosylcobalamin
dAdoCbl)
pyridoxal-5'-phosphate (PLP
vitamin B6)
lysine 5,6-aminomutase
ornithine 4,5-aminomutase
isotope-edited electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) spectroscopy
density functional theory (DFT)
Online Access:http://www.mdpi.com/1422-0067/15/2/3064

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