ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway

ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway

Osteosarcoma (OS) is a familiar malignant bone tumor that occurs mainly in adolescents. Immature colon carcinoma transcript-1 (ICT1) is an important member of the large mitoribosomal subunit in mitochondrial ribosomes, which has been shown to be closely related to tumorigenesis. Its expression and f...

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Main Authors: Xiaohui Pan, Jingxue Tan, Xiaokun Weng, Rui Du, Yuqing Jiang, Yiping Weng, Dong Zhou, Yifei Shen
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2021/8971728
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spelling doaj-8890a44a35ff417a9dcc4d2e501a807c2021-02-15T12:52:45ZengHindawi LimitedBioMed Research International2314-61332314-61412021-01-01202110.1155/2021/89717288971728ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 PathwayXiaohui Pan0Jingxue Tan1Xiaokun Weng2Rui Du3Yuqing Jiang4Yiping Weng5Dong Zhou6Yifei Shen7Department of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Radiotherapy, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Foot and Ankle Surgery, Binzhou Medical University Hospital, Binzhou, 256600 Shandong Province, ChinaDepartment of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaDepartment of Orthopedics, The Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People’s Hospital, Changzhou, Jiangsu 213003, ChinaOsteosarcoma (OS) is a familiar malignant bone tumor that occurs mainly in adolescents. Immature colon carcinoma transcript-1 (ICT1) is an important member of the large mitoribosomal subunit in mitochondrial ribosomes, which has been shown to be closely related to tumorigenesis. Its expression and function in OS, however, remained unclear. Here, we showed that ICT1 was significantly upregulated in OS and promoted the growth of OS cells. Mechanistically, ICT1 acted as an oncogene in OS and promoted proliferation and inhibited apoptosis of OS cells through the STAT3/BCL-2 axis. These results reveal a novel insight into the role of the ICT1/STAT3/BCL-2 axis in OS and therefore may represent a novel molecular target for novel treatments.http://dx.doi.org/10.1155/2021/8971728
collection DOAJ
language English
format Article
sources DOAJ
author Xiaohui Pan
Jingxue Tan
Xiaokun Weng
Rui Du
Yuqing Jiang
Yiping Weng
Dong Zhou
Yifei Shen
spellingShingle Xiaohui Pan
Jingxue Tan
Xiaokun Weng
Rui Du
Yuqing Jiang
Yiping Weng
Dong Zhou
Yifei Shen
ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
BioMed Research International
author_facet Xiaohui Pan
Jingxue Tan
Xiaokun Weng
Rui Du
Yuqing Jiang
Yiping Weng
Dong Zhou
Yifei Shen
author_sort Xiaohui Pan
title ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
title_short ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
title_full ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
title_fullStr ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
title_full_unstemmed ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits Apoptosis via STAT3/BCL-2 Pathway
title_sort ict1 promotes osteosarcoma cell proliferation and inhibits apoptosis via stat3/bcl-2 pathway
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2021-01-01
description Osteosarcoma (OS) is a familiar malignant bone tumor that occurs mainly in adolescents. Immature colon carcinoma transcript-1 (ICT1) is an important member of the large mitoribosomal subunit in mitochondrial ribosomes, which has been shown to be closely related to tumorigenesis. Its expression and function in OS, however, remained unclear. Here, we showed that ICT1 was significantly upregulated in OS and promoted the growth of OS cells. Mechanistically, ICT1 acted as an oncogene in OS and promoted proliferation and inhibited apoptosis of OS cells through the STAT3/BCL-2 axis. These results reveal a novel insight into the role of the ICT1/STAT3/BCL-2 axis in OS and therefore may represent a novel molecular target for novel treatments.
url http://dx.doi.org/10.1155/2021/8971728
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