Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitrogen for the α-carbon of the aspartate residue in the sweetener S,S-aspartame. Considering that S,S- and R,S-aspartame possess sweet and bitter tastes, respectively, a bitter-sweet taste of aza-aspart...

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Bibliographic Details
Main Authors: Samir H. Bouayad-Gervais, William D. Lubell
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
azapeptide
peptide mimic
aspartame
dynamic chirality
hydrazine
taste
crystal structure
nitrogen chirality
semicarbazide
Online Access:http://www.mdpi.com/1420-3049/18/12/14739

Internet

http://www.mdpi.com/1420-3049/18/12/14739

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