Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors

Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffold...

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Main Authors:	Gian Nutal Schädli, Jolanda R. Vetsch, Robert P. Baumann, Anke M. de Leeuw, Esther Wehrle, Marina Rubert, Ralph Müller
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-020-01635-4

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spelling	doaj-887e194078584a6e9ab137b67f229d0e2021-01-31T16:16:45ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111410.1038/s42003-020-01635-4Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactorsGian Nutal Schädli0Jolanda R. Vetsch1Robert P. Baumann2Anke M. de Leeuw3Esther Wehrle4Marina Rubert5Ralph Müller6Institute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichInstitute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichParticle Technology Laboratory, Department of Mechanical and Process Engineering, ETH ZurichInstitute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichInstitute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichInstitute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichInstitute for Biomechanics, Department of Health Sciences and Technology, ETH ZurichSchädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffolds performance in vitro and might reduce the use of animals for experimentation.https://doi.org/10.1038/s42003-020-01635-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller
spellingShingle	Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors Communications Biology
author_facet	Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller
author_sort	Gian Nutal Schädli
title	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_short	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_full	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_fullStr	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_full_unstemmed	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_sort	time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-01-01
description	Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffolds performance in vitro and might reduce the use of animals for experimentation.
url	https://doi.org/10.1038/s42003-020-01635-4
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Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors

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