Mutator/hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis.

Mutator/hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis.

Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1957) postulated that the exponential increase resulted from n mutations occurring throughout adult life in normal cells at risk that initia...

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Bibliographic Details
Main Authors: Lohith G. Kini, Pablo eHerrero-Jimenez, Emma E. Furth, Tushar eKamath, Jayodita eSanghvi, Efren eGutierrez, David eHensle, John eKogel, Rebecca eKusko, Karl eRexer, Ray eKurzweil, Paulo eRefinetti, Stephan eMorgenthaler, Vera V. Koledova, Elena V. Gostjeva, William G. Thilly
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Oncology
Subjects:
Stem Cells
Mutator
metakaryotic
hypermutable
cancer model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00267/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00267/full

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