Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans

• Main Authors: Mi-Young Song, Sang Hoon Kim, Ga-Hee Ryoo, Mi-Kyung Kim, Hye-Na Cha, So-Young Park, Hong Pil Hwang, Hee Chul Yu, Eun Ju Bae, Byung-Hyun Park
• Format: Article
• Language: English
• Published: Nature Publishing Group 2019-05-01
• Series: Experimental and Molecular Medicine
• Online Access: https://doi.org/10.1038/s12276-019-0256-9
• ISSN: 1226-3613; 2092-6413

Obesity and diabetes: A control protein in fat A protein in adipose tissue (composed of fat cells) helps protect against inflammation and the development of resistance to insulin that develops in obesity and can lead to type 2 diabetes. Researchers in South Korea, led by Eun Ju Bae at Woosuk University, Wanju, and Byung-Hyun Park at Chonbuk National University, Jeonju, investigated the role of Sirt6 in mice and in human adipose tissue. Deleting the mouse gene that codes for Sirt6 in adipocytes promoted the impaired response to insulin and associated increase in blood glucose levels that are two key aspects of diabetes. Changes in biochemical signaling pathways controlling immune cells called macrophages were implicated in these effects and suggest an anti-inflammatory role for Sirt6. Analysis of human adipose tissue supported these findings. The research will help understand how obesity promotes type 2 diabetes.