Protective Effect of <i>Potentilla glabra</i> in UVB-Induced Photoaging Process

• Main Authors: Long You, Mi-Yeon Kim, Jae Youl Cho
• Format: Article
• Language: English
• Published: MDPI AG 2021-09-01
• Series: Molecules
• Subjects: AP-1; moisturizing; photoaging; <i>Potentilla glabra</i> var. <i>mandshurica</i> (Maxim.) Hand.-Mazz.; skin protection
• Online Access: https://www.mdpi.com/1420-3049/26/17/5408

Maintaining skin homeostasis is one of the most important factors for skin health. UVB-induced skin photoaging is a difficult problem that has negative impacts on skin homeostasis. So far, a number of compounds have been discovered that improve human skin barrier function and hydration, and are thought to be effective ways to protect skin homeostasis. <i>Potentilla glabra</i> var. <i>mandshurica</i> (Maxim.) Hand.-Mazz. Ethanol Extract (Pg-EE) is a compound that has noteworthy anti-inflammatory properties. However, its skin-protective effects are poorly understood. Therefore, we evaluated the capacity of Pg-EE to strengthen the skin barrier and improve skin hydration. Pg-EE can enhance the expression of <i>filaggrin (FLG)</i>, <i>transglutaminase (TGM)-1</i>, <i>hyaluronic acid synthase (HAS)-1</i>, and <i>HAS-2</i> in human keratinocytes. Moreover, Pg-EE down-regulated the expression of pro-inflammatory cytokines and up-regulated the production of <i>FLG</i>, <i>HAS-1</i>, and <i>HAS-2</i> suppressed by UVB through inhibition of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) pathways. Given the above, since Pg-EE can improve skin barrier, hydration and reduce the UVB-induced inflammation on skin, it could therefore be a valuable natural ingredient for cosmetics or pharmaceuticals to treat skin disorders.