Regulation effect of S-nitroso-N-acetylcysteine on target organ damage and oxidative stress induced by pyocyanin infection
Objective: To study the regulation effect of S-nitroso-N-acetylcysteine on target organ damage and oxidative stress induced by pyocyanin infection. Methods: Adult male SD rats were randomly divided into control group, NaCl group and SNAC group, both NaCl group and SNAC group received intratrachea...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-01-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201602/4.pdf |
Summary: | Objective: To study the regulation effect of S-nitroso-N-acetylcysteine on target organ
damage and oxidative stress induced by pyocyanin infection. Methods: Adult male SD rats
were randomly divided into control group, NaCl group and SNAC group, both NaCl group
and SNAC group received intratracheal inoculation of pyocyanin, and SNAC group received
S-nitroso-N-acetylcysteine intraperitoneal injection treatment. Then inflammatory mediator
contents in serum as well as number of apoptosis cells, NO content, oxidation reaction product
contents and endoplasmic reticulum stress marker molecule expression in lung tissue of three
groups were compared. Results: Contents of IL-1 β, IL-6 and TNF-α in serum and number
of apoptosis cells in lung tissue of NaCl group were significantly higher than those of control
group, and contents of IL-1 β, IL-6 and TNF-α in serum and number of apoptosis cells in
lung tissue of SNAC group were significantly lower than those of NaCl group; NO content in
lung tissue of NaCl group was significantly lower than that of control group, and NO content
in lung tissue of SNAC group was significantly higher than that of NaCl group; MDA, AOPP,
8-OhdG and GRP78 levels in lung tissue of NaCl group were significantly higher than those
of control group, and MDA, AOPP, 8-OhdG and GRP78 levels in lung tissue of SNAC group
were significantly lower than those of NaCl group. Conclusion: S-nitroso-N-acetylcysteine can
protect lung damage induced by pyocyanin infection, relieve inflammation, inhibit apoptosis
and reduce oxidative stress. |
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ISSN: | 1007-1237 1007-1237 |