3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies

3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies

The current pharmacological Chagas disease treatments, using Nifurtimox or Benznidazole, show limited therapeutic results and are associated with potential side effects, like mutagenicity. Using random screening we have identified new chemotypes that were able to inhibit relevant targets of the Tryp...

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Bibliographic Details
Main Authors: Marcos Couto, Carina Sánchez, Belén Dávila, Valentina Machín, Javier Varela, Guzmán Álvarez, Mauricio Cabrera, Laura Celano, Beatriz Aguirre-López, Nallely Cabrera, Marieta Tuena de Gómez-Puyou, Armando Gómez-Puyou, Ruy Pérez-Montfort, Hugo Cerecetto, Mercedes González
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
anti-T. cruzi activity
3H-1,2-dithiole
triosephosphate isomerase
cruzipain
membrane sterol biosynthesis
1H-NMR metabolomics
Online Access:http://www.mdpi.com/1420-3049/20/8/14595

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