β-Amyloid(1-42)-Induced Cholinergic Lesions in Rat Nucleus Basalis Bidirectionally Modulate Serotonergic Innervation of the Basal Forebrain and Cerebral Cortex

β-Amyloid(1-42)-Induced Cholinergic Lesions in Rat Nucleus Basalis Bidirectionally Modulate Serotonergic Innervation of the Basal Forebrain and Cerebral Cortex

Ample experimental evidence suggests that β-amyloid (Aβ), when injected into the rat magnocellular nucleus basalis (MBN), impels excitotoxic injury of cholinergic projection neurons. Whereas learning and memory dysfunction is a hallmark of Aβ-induced cholinergic deficits, anxiety, or hypoactivity un...

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Bibliographic Details
Main Authors: Tibor Harkany, Sheila O'Mahony, Jan Keijser, John P. Kelly, Csaba Kónya, Zsolt A. Borostyánkői, Tamás J. Görcs, Márta Zarándi, Botond Penke, Brian E. Leonard, Paul G.M. Luiten
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Neurobiology of Disease
Subjects:
β-Amyloid
anxiety
magnocellular nucleus basalis
serotonin
sprouting
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101903985

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http://www.sciencedirect.com/science/article/pii/S0969996101903985

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