The molecular pathways underlying host resistance and tolerance to pathogens

Breeding livestock that are better able to withstand the onslaught of endemic and exotic pathogens is high on the wish list of breeders and farmers world-wide. However the defence systems in both pathogens and their hosts are complex and the degree of genetic variation in resistance and tolerance w...

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Main Author: Elizabeth Janet Glass
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Genetics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00263/full
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spelling doaj-883d4c363f5a4bdeb57f0273fa60578a2020-11-24T23:02:35ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-12-01310.3389/fgene.2012.0026333796The molecular pathways underlying host resistance and tolerance to pathogensElizabeth Janet Glass0The University of EdinburghBreeding livestock that are better able to withstand the onslaught of endemic and exotic pathogens is high on the wish list of breeders and farmers world-wide. However the defence systems in both pathogens and their hosts are complex and the degree of genetic variation in resistance and tolerance will depend on the trade-offs that they impose on host fitness as well as their life-histories. The genes and pathways underpinning resistance and tolerance traits may be distinct or intertwined as the outcome of any infection is a result of a balance between collateral damage of host tissues and control of the invading pathogen. Genes and molecular pathways associated with resistance are mainly expressed in the mucosal tract and the innate immune system and control the very early events following pathogen invasion. Resistance genes encode receptors involved in uptake of pathogens, as well as pattern recognition receptors (PRR) such as the toll-like receptor family as well as molecules involved in strong and rapid inflammatory responses which lead to rapid pathogen clearance yet do not lead to immunopathology. In contrast tolerance genes and pathways play a role in reducing immunopathology or enhancing the host’s ability to protect against pathogen associated toxins. Candidate tolerance genes may include cytosolic PRRs and unidentified sensors of pathogen growth, perturbation of host metabolism and intrinsic danger or damage associated molecules. In addition, genes controlling regulatory pathways, tissue repair and resolution are also tolerance candidates. The identities of distinct genetic loci for resistance and tolerance to infectious pathogens in livestock species remain to be determined. A better understanding of the mechanisms involved and phenotypes associated with resistance and tolerance should ultimately help to improve livestock health and welfare.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00263/fullBreedingDisease ResistanceGeneticsImmunityInflammationLivestock
collection DOAJ
language English
format Article
sources DOAJ
author Elizabeth Janet Glass
spellingShingle Elizabeth Janet Glass
The molecular pathways underlying host resistance and tolerance to pathogens
Frontiers in Genetics
Breeding
Disease Resistance
Genetics
Immunity
Inflammation
Livestock
author_facet Elizabeth Janet Glass
author_sort Elizabeth Janet Glass
title The molecular pathways underlying host resistance and tolerance to pathogens
title_short The molecular pathways underlying host resistance and tolerance to pathogens
title_full The molecular pathways underlying host resistance and tolerance to pathogens
title_fullStr The molecular pathways underlying host resistance and tolerance to pathogens
title_full_unstemmed The molecular pathways underlying host resistance and tolerance to pathogens
title_sort molecular pathways underlying host resistance and tolerance to pathogens
publisher Frontiers Media S.A.
series Frontiers in Genetics
issn 1664-8021
publishDate 2012-12-01
description Breeding livestock that are better able to withstand the onslaught of endemic and exotic pathogens is high on the wish list of breeders and farmers world-wide. However the defence systems in both pathogens and their hosts are complex and the degree of genetic variation in resistance and tolerance will depend on the trade-offs that they impose on host fitness as well as their life-histories. The genes and pathways underpinning resistance and tolerance traits may be distinct or intertwined as the outcome of any infection is a result of a balance between collateral damage of host tissues and control of the invading pathogen. Genes and molecular pathways associated with resistance are mainly expressed in the mucosal tract and the innate immune system and control the very early events following pathogen invasion. Resistance genes encode receptors involved in uptake of pathogens, as well as pattern recognition receptors (PRR) such as the toll-like receptor family as well as molecules involved in strong and rapid inflammatory responses which lead to rapid pathogen clearance yet do not lead to immunopathology. In contrast tolerance genes and pathways play a role in reducing immunopathology or enhancing the host’s ability to protect against pathogen associated toxins. Candidate tolerance genes may include cytosolic PRRs and unidentified sensors of pathogen growth, perturbation of host metabolism and intrinsic danger or damage associated molecules. In addition, genes controlling regulatory pathways, tissue repair and resolution are also tolerance candidates. The identities of distinct genetic loci for resistance and tolerance to infectious pathogens in livestock species remain to be determined. A better understanding of the mechanisms involved and phenotypes associated with resistance and tolerance should ultimately help to improve livestock health and welfare.
topic Breeding
Disease Resistance
Genetics
Immunity
Inflammation
Livestock
url http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00263/full
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