| Summary: | Background: Investigations have revealed the Western Ontario and McMaster Universities Osteoarthritis Index’s (WOMAC) inability to provide distinct assessments of pain and function. The Lower Extremity Functional Scale (LEFS) has not displayed this deficiency. Our purposes were to investigate further the WOMAC physical function's (WOMAC-PF) ability to accurately assess lower extremity mobility in patients undergoing total knee arthroplasty (TKA) and to establish a relationship between pre- and post-TKA WOMAC-PF and LEFS scores that accounts for the apparent bias WOMAC pain scores impose on WOMAC-PF scores. Methods: WOMAC, LEFS, and Timed-up-and-go measures were administered before TKA and 4 days, 6 weeks, and 3 months after TKA. To evaluate the WOMAC-PF and LEFS ability to provide a distinct assessment of pain and function, a paired t-test compared pre-TKA and 4 days after TKA values. Generalized estimating equation (GEE) analysis assessed the relationship between pre- and post-TKA values: dependent variable WOMAC-PF scores; independent variables LEFS scores, and measurement occasions. Results: Timed-up-and-go and LEFS demonstrated a reduction in lower extremity function (P < .001); pain decreased (P < .001); and there was no significant change in WOMAC-PF scores (P = .61). GEE analysis revealed a linear relationship between WOMAC-PF and LEFS with similar slope coefficients for all four occasions. The relationship between WOMAC-PF and LEFS scores was virtually identical for the postarthroplasty assessment occasions. Conclusions: Our findings support previous investigations that showed the WOMAC-PF’s inability to provide a valid assessment in change in function. The GEE analysis coefficients can be used to convert LEFS scores to WOMAC-PF scores that adjust for the bias between pre- and post-TKA assessments. Keywords: Outcome measures, Knee arthroplasty, Patient-reported
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