Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1‐phosphate in extravillous trophoblasts

Sphingosine kinases negatively regulate the expression of matrix metalloproteases (MMP1 and MMP3) and their inhibitor TIMP3 genes via sphingosine 1‐phosphate in extravillous trophoblasts

Abstract Purpose Extracellular matrix remodeling is essential for extravillous trophoblast (EVT) cell migration and invasion during placental development and regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteases (TIMPs). Sphingosine kinases (SPHK1 and SPHK2) synthes...

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Bibliographic Details
Main Authors: Kirti R. Chahar, Vijay Kumar, Phulwanti K. Sharma, Daniela Brünnert, Vibha Kaushik, Pragya Gehlot, Indu Shekhawat, Suman Kumar, Ajay Kumar Sharma, Sandhya Kumari, Pankaj Goyal
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Reproductive Medicine and Biology
Subjects:
extravillous trophoblast
matrix metalloproteinases
Sphingosine 1‐phosphate
Sphingosine kinase
tissue inhibitors of metalloproteases
Online Access:https://doi.org/10.1002/rmb2.12379

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