Characteristics of BRCA1/2 pathogenic germline mutations in chinese NSCLC patients and a comparison with HBOC

Characteristics of BRCA1/2 pathogenic germline mutations in chinese NSCLC patients and a comparison with HBOC

Abstract Background and purposes The pathogenic BRCA1/2 germline mutations contributed to Hereditary Breast and Ovarian Cancer (HBOC) susceptibility. The features of BRCA1/2 germline mutations in non-small cell lung cancer (NSCLC) have not been systematically studied. Here we performed the first stu...

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Bibliographic Details
Main Authors: Zheyuan Xu, Yang Wang, Lan Wang, Fengxian Cui, Libin Zhang, Jian Xiong, Hao Peng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
Lung cancer
HBOC
BRCA1
BRCA2
Germline
Frameshift
Online Access:https://doi.org/10.1186/s13053-021-00174-1

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