Theoretical principles of transcription factor traffic on folded chromatin
How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04130-x |
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doaj-8818853b5c76420db353655d10fd7053 |
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Article |
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doaj-8818853b5c76420db353655d10fd70532021-05-11T09:41:25ZengNature Publishing GroupNature Communications2041-17232018-04-019111010.1038/s41467-018-04130-xTheoretical principles of transcription factor traffic on folded chromatinRuggero Cortini0Guillaume J. Filion1Genome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyGenome Architecture, Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyHow transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process.https://doi.org/10.1038/s41467-018-04130-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ruggero Cortini Guillaume J. Filion |
| spellingShingle |
Ruggero Cortini Guillaume J. Filion Theoretical principles of transcription factor traffic on folded chromatin Nature Communications |
| author_facet |
Ruggero Cortini Guillaume J. Filion |
| author_sort |
Ruggero Cortini |
| title |
Theoretical principles of transcription factor traffic on folded chromatin |
| title_short |
Theoretical principles of transcription factor traffic on folded chromatin |
| title_full |
Theoretical principles of transcription factor traffic on folded chromatin |
| title_fullStr |
Theoretical principles of transcription factor traffic on folded chromatin |
| title_full_unstemmed |
Theoretical principles of transcription factor traffic on folded chromatin |
| title_sort |
theoretical principles of transcription factor traffic on folded chromatin |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-04-01 |
| description |
How transcription factors find their targets in vivo is still poorly understood. Here the authors use molecular dynamics simulations to investigate how transcription factors diffuse on chromatin, providing a theoretical framework for understanding the key role of genome conformation in this process. |
| url |
https://doi.org/10.1038/s41467-018-04130-x |
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