Glucose‐induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs

Glucose‐induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs

Abstract Diabetic complications cause significant morbidity and mortality. Dysfunction of vascular endothelial cells (ECs), caused by oxidative stress, is a main mechanism of cellular damage. Oxidative stress accelerates EC senescence and DNA damage. In this study, we examined the role of mitochondr...

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Bibliographic Details
Main Authors: Jieting Liu, Shali Chen, Saumik Biswas, Niharika Nagrani, Yanhui Chu, Subrata Chakrabarti, Biao Feng
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Physiological Reports
Subjects:
aging
diabetic complications
endothelial cells
miRNAs
SIRT
Online Access:https://doi.org/10.14814/phy2.14331

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