CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy

CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy

Cancer is a threat to human health and life. Although previously centered on chemical drug treatments, cancer treatment has entered an era of precision targeted therapy. Targeted therapy entails precise guidance, allowing the selective killing of cancer cells and thereby reducing damage to healthy t...

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Bibliographic Details
Main Authors: Wenwen Shi, Qiudi Huang, Jiacui Xie, He Wang, Xiyong Yu, Yi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
drug resistance
therapeutic target
cell cycling
human cancers
CKS1B
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.582451/full
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spelling doaj-880fd59096e04686be21976350fef1ca2020-11-25T03:52:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.582451582451CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer TherapyWenwen Shi0Qiudi Huang1Jiacui Xie2He Wang3Xiyong Yu4Yi Zhou5Key Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaCenter of Cancer Research, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaKey Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaCancer is a threat to human health and life. Although previously centered on chemical drug treatments, cancer treatment has entered an era of precision targeted therapy. Targeted therapy entails precise guidance, allowing the selective killing of cancer cells and thereby reducing damage to healthy tissues. Therefore, the need to explore potential targets for tumor treatment is vital. Cyclin-dependent kinase regulatory subunit 1B (CKS1B), a member of the conserved cyclin kinase subunit 1 (CKS1) protein family, plays an essential role in cell cycling. A large number of studies have shown that CKS1B is associated with the pathogenesis of many human cancers and closely related to drug resistance. Here, we describe the current understanding of the cellular functions of CKS1B and its underlying mechanisms, summarize a recent study of CKS1B as a target for cancer treatment and discuss the potential of CKS1B as a therapeutic target.https://www.frontiersin.org/article/10.3389/fonc.2020.582451/fulldrug resistancetherapeutic targetcell cyclinghuman cancersCKS1B
collection DOAJ
language English
format Article
sources DOAJ
author Wenwen Shi
Qiudi Huang
Jiacui Xie
He Wang
Xiyong Yu
Yi Zhou
spellingShingle Wenwen Shi
Qiudi Huang
Jiacui Xie
He Wang
Xiyong Yu
Yi Zhou
CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
Frontiers in Oncology
drug resistance
therapeutic target
cell cycling
human cancers
CKS1B
author_facet Wenwen Shi
Qiudi Huang
Jiacui Xie
He Wang
Xiyong Yu
Yi Zhou
author_sort Wenwen Shi
title CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
title_short CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
title_full CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
title_fullStr CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
title_full_unstemmed CKS1B as Drug Resistance-Inducing Gene—A Potential Target to Improve Cancer Therapy
title_sort cks1b as drug resistance-inducing gene—a potential target to improve cancer therapy
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2020-09-01
description Cancer is a threat to human health and life. Although previously centered on chemical drug treatments, cancer treatment has entered an era of precision targeted therapy. Targeted therapy entails precise guidance, allowing the selective killing of cancer cells and thereby reducing damage to healthy tissues. Therefore, the need to explore potential targets for tumor treatment is vital. Cyclin-dependent kinase regulatory subunit 1B (CKS1B), a member of the conserved cyclin kinase subunit 1 (CKS1) protein family, plays an essential role in cell cycling. A large number of studies have shown that CKS1B is associated with the pathogenesis of many human cancers and closely related to drug resistance. Here, we describe the current understanding of the cellular functions of CKS1B and its underlying mechanisms, summarize a recent study of CKS1B as a target for cancer treatment and discuss the potential of CKS1B as a therapeutic target.
topic drug resistance
therapeutic target
cell cycling
human cancers
CKS1B
url https://www.frontiersin.org/article/10.3389/fonc.2020.582451/full
work_keys_str_mv AT wenwenshi cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
AT qiudihuang cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
AT jiacuixie cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
AT hewang cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
AT xiyongyu cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
AT yizhou cks1basdrugresistanceinducinggeneapotentialtargettoimprovecancertherapy
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