Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies

Characterisation of the Structure and Oligomerisation of Islet Amyloid Polypeptides (IAPP): A Review of Molecular Dynamics Simulation Studies

Human islet amyloid polypeptide (hIAPP) is a naturally occurring, intrinsically disordered protein whose abnormal aggregation into amyloid fibrils is a pathological feature in type 2 diabetes, and its cross-aggregation with amyloid beta has been linked to an increased risk of Alzheimer’s d...

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Bibliographic Details
Main Authors: Sandra J. Moore, Krushna Sonar, Prashant Bharadwaj, Evelyne Deplazes, Ricardo L. Mancera
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
amyloidogenesis
protein aggregation
molecular simulation
Online Access:http://www.mdpi.com/1420-3049/23/9/2142

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