Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of model...
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MDPI AG
2017-12-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | https://www.mdpi.com/2221-3759/6/1/1 |
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doaj-8806f4705f7746c3a70a55a45bb3d48a2020-11-25T00:09:00ZengMDPI AGJournal of Developmental Biology2221-37592017-12-0161110.3390/jdb6010001jdb6010001Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic SystemsChu Hsien Lim0Ajay S. Mathuru1Yale NUS College, 16 College Avenue West, Singapore 138610, SingaporeYale NUS College, 16 College Avenue West, Singapore 138610, SingaporeModeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.https://www.mdpi.com/2221-3759/6/1/1Alzheimer’s diseaseCRY2Drosophila melanogasterCaenorhabditis elegansDanio reriooptogenetics |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chu Hsien Lim Ajay S. Mathuru |
| spellingShingle |
Chu Hsien Lim Ajay S. Mathuru Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems Journal of Developmental Biology Alzheimer’s disease CRY2 Drosophila melanogaster Caenorhabditis elegans Danio rerio optogenetics |
| author_facet |
Chu Hsien Lim Ajay S. Mathuru |
| author_sort |
Chu Hsien Lim |
| title |
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems |
| title_short |
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems |
| title_full |
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems |
| title_fullStr |
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems |
| title_full_unstemmed |
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems |
| title_sort |
modeling alzheimer’s and other age related human diseases in embryonic systems |
| publisher |
MDPI AG |
| series |
Journal of Developmental Biology |
| issn |
2221-3759 |
| publishDate |
2017-12-01 |
| description |
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease. |
| topic |
Alzheimer’s disease CRY2 Drosophila melanogaster Caenorhabditis elegans Danio rerio optogenetics |
| url |
https://www.mdpi.com/2221-3759/6/1/1 |
| work_keys_str_mv |
AT chuhsienlim modelingalzheimersandotheragerelatedhumandiseasesinembryonicsystems AT ajaysmathuru modelingalzheimersandotheragerelatedhumandiseasesinembryonicsystems |
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1725413442838331392 |