ANTIBIOTIC RESISTANCE OF HELICOBACTER PYLORI AMONG CHILDREN AND THERAPY SELECTION

• Main Authors: Ye.A. Kornienko, N.I. Parolova
• Format: Article
• Language: English
• Published: "Paediatrician" Publishers LLC 2006-01-01
• Series: Voprosy Sovremennoj Pediatrii
• Online Access: http://vsp.spr-journal.ru:80/jour/article/view/812

<p>The reason for the low therapy efficiency of many gastrobduodenal diseases is the increasing resistance to the antibiotics <em>helicobacter pylori (Н. pylori), </em>which is conditioned by the mutations of its various genes. The most practical importance is attributed to the 23s RRNA mutations, underlying resistance to claritromicin. According to the international consensus maastrichtb3, the scheme of treatment with the inhibitor of the proton pump, claritromicin and metronidasol is recommended as the 1st line therapy. The present work assesses the resistance of <em>Н. pylori </em>to claritromicin aided by pcrbdiagnostics of the 23s RRNA mutation of rna in the biopsy material of the mucous coat of stomach and standard treatment scheme efficiency if compared with the onebantibiotic scheme – amoxicillin, bismuth and inhibitor of the proton pump. 68 children with <em>Н. pylori </em>bassociated diseases have been examined. The frequency of resistance of <em>Н. pylori </em>to claritromicin made up 28%. The standard 10bday long scheme of treatment was efficient among 14% of the patients, the 7bday long schemes with amoxicillin, bismuth and omeprazole were efficient among 40% of the patients, the 10bday long schemes with amoxicillin, bismuth and omeprazole were efficient among 75% of the patients; with omeprazole replaced by esomeprazole the efficiency was observed among 83% of the patients along with the good treatment tolerance.</p><p><strong><em>Key words: helicobacter pylori, antibiotic resistance, eradication.</em></strong></p>