LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

Abstract Aim Myocardial infarction (MI) is a severe disease with increased mortality and disability rates, posing heavy economic burden for society. Exosomes were uncovered to mediate intercellular communication after MI. This study aims to explore the effect and mechanism of lncRNA KLF3-AS1 in exos...

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Bibliographic Details
Main Authors: Qing Mao, Xiu-Lin Liang, Chuan-Long Zhang, Yi-Heng Pang, Yong-Xiang Lu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Stem Cell Research & Therapy
Subjects:
Exosome
Pyroptosis
Myocardial infarction
Human mesenchymal stem cells
KLF3-AS1
miR-138-5p
Online Access:https://doi.org/10.1186/s13287-019-1522-4

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