Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

MicroRNAs (miRNAs) act as regulators of aging at the tissue or organism level or as regulators of cellular senescence. Targeted deletion of miR-126 in mice causes partial embryonic lethality, but its biological function in the liver is still largely unknown. Here, we deleted miR-126a, using the CRIS...

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Bibliographic Details
Main Authors:	Yi Yan, Dan Qin, Bian Hu, Chunjing Zhang, Shenghui Liu, Dongde Wu, Wendong Huang, Xingxu Huang, Liqiang Wang, Xiangmei Chen, Lisheng Zhang
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	Molecular Therapy: Nucleic Acids
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253119300757

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