Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known...

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Main Authors:	Yu Dai, Kunlong Li, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, Yonghong Liu
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Marine Drugs
Subjects:	lipopeptides phthalide <i>Cochliobolus lunatus</i> absolute configurations AChE inhibitory
Online Access:	https://www.mdpi.com/1660-3397/18/11/547

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record_format	Article
spelling	doaj-87edd93dceac4bda88af418b21982f962020-11-25T03:09:25ZengMDPI AGMarine Drugs1660-33972020-10-011854754710.3390/md18110547Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401Yu Dai0Kunlong Li1Jianglian She2Yanbo Zeng3Hao Wang4Shengrong Liao5Xiuping Lin6Bin Yang7Junfeng Wang8Huaming Tao9Haofu Dai10Xuefeng Zhou11Yonghong Liu12CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaResearch and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, ChinaResearch and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaResearch and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaA pair of novel lipopeptide epimers, sinulariapeptides A (<b>1</b>) and B (<b>2</b>), and a new phthalide glycerol ether (<b>3</b>) were isolated from the marine algal-associated fungus <i>Cochliobolus lunatus</i> SCSIO41401, together with three known chromanone derivates (<b>4</b>–<b>6</b>). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo<sub>2 </sub>(OAc)<sub>4</sub>-induced ECD methods. The new compounds <b>1</b>–<b>3</b> showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC<sub>50</sub> values of 1.3–2.5 μM, and an in silico molecular docking study was also performed.https://www.mdpi.com/1660-3397/18/11/547lipopeptidesphthalide<i>Cochliobolus lunatus</i>absolute configurationsAChE inhibitory
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu Dai Kunlong Li Jianglian She Yanbo Zeng Hao Wang Shengrong Liao Xiuping Lin Bin Yang Junfeng Wang Huaming Tao Haofu Dai Xuefeng Zhou Yonghong Liu
spellingShingle	Yu Dai Kunlong Li Jianglian She Yanbo Zeng Hao Wang Shengrong Liao Xiuping Lin Bin Yang Junfeng Wang Huaming Tao Haofu Dai Xuefeng Zhou Yonghong Liu Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401 Marine Drugs lipopeptides phthalide <i>Cochliobolus lunatus</i> absolute configurations AChE inhibitory
author_facet	Yu Dai Kunlong Li Jianglian She Yanbo Zeng Hao Wang Shengrong Liao Xiuping Lin Bin Yang Junfeng Wang Huaming Tao Haofu Dai Xuefeng Zhou Yonghong Liu
author_sort	Yu Dai
title	Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401
title_short	Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401
title_full	Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401
title_fullStr	Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401
title_full_unstemmed	Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401
title_sort	lipopeptide epimers and a phthalide glycerol ether with ache inhibitory activities from the marine-derived fungus <i>cochliobolus lunatus </i>scsio41401
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2020-10-01
description	A pair of novel lipopeptide epimers, sinulariapeptides A (<b>1</b>) and B (<b>2</b>), and a new phthalide glycerol ether (<b>3</b>) were isolated from the marine algal-associated fungus <i>Cochliobolus lunatus</i> SCSIO41401, together with three known chromanone derivates (<b>4</b>–<b>6</b>). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo<sub>2 </sub>(OAc)<sub>4</sub>-induced ECD methods. The new compounds <b>1</b>–<b>3</b> showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC<sub>50</sub> values of 1.3–2.5 μM, and an in silico molecular docking study was also performed.
topic	lipopeptides phthalide <i>Cochliobolus lunatus</i> absolute configurations AChE inhibitory
url	https://www.mdpi.com/1660-3397/18/11/547
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Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401

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