Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus <i>Cochliobolus Lunatus </i>SCSIO41401

• Main Authors: Yu Dai, Kunlong Li, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, Yonghong Liu
• Format: Article
• Language: English
• Published: MDPI AG 2020-10-01
• Series: Marine Drugs
• Subjects: lipopeptides; phthalide; <i>Cochliobolus lunatus</i>; absolute configurations; AChE inhibitory
• Online Access: https://www.mdpi.com/1660-3397/18/11/547
• ISSN: 1660-3397

A pair of novel lipopeptide epimers, sinulariapeptides A (<b>1</b>) and B (<b>2</b>), and a new phthalide glycerol ether (<b>3</b>) were isolated from the marine algal-associated fungus <i>Cochliobolus lunatus</i> SCSIO41401, together with three known chromanone derivates (<b>4</b>–<b>6</b>). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo₂(OAc)₄-induced ECD methods. The new compounds <b>1</b>–<b>3</b> showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC₅₀ values of 1.3–2.5 μM, and an in silico molecular docking study was also performed.