An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Abstract Background Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading to about 50% of patient relapse by increasing AML burden in the bone marrow, blood, and extramedullar sites. We developed a protein-based nanoparticle conjugated...

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Bibliographic Details
Main Authors: Victor Pallarès, Ugutz Unzueta, Aïda Falgàs, Laura Sánchez-García, Naroa Serna, Alberto Gallardo, Gordon A. Morris, Lorena Alba-Castellón, Patricia Álamo, Jorge Sierra, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Ramon Mangues
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia
CXCR4
Targeted nanoparticle
Auristatin nanoconjugate
Leukemic stem cells
Disseminated AML mouse model
Online Access:http://link.springer.com/article/10.1186/s13045-020-00863-9

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