Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells

Previous work has shown that although estrogen (E2) disrupts cellular iron metabolism and induces oxidative stress in breast and ovarian cancer cells, it fails to induce apoptosis. However, E2 treatment was reported to enhance the apoptotic effects of doxorubicin in cancer cells. This suggests that...

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Bibliographic Details
Main Authors: Khuloud Bajbouj, Jasmin Shafarin, Jalal Taneera, Mawieh Hamad
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biology
Subjects:
Estrogen
senescence
MCF-7
MDA-MB-231
mitochondria
autophagy
Online Access:https://www.mdpi.com/2079-7737/9/4/68

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