Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems

Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems

Bacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-i...

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Main Authors: Christopher M. Bellas, Declan C. Schroeder, Arwyn Edwards, Gary Barker, Alexandre M. Anesio
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18236-8
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spelling doaj-87e483e9dc33413790e4656412d76b4c2021-09-05T11:45:02ZengNature Publishing GroupNature Communications2041-17232020-09-0111111010.1038/s41467-020-18236-8Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystemsChristopher M. Bellas0Declan C. Schroeder1Arwyn Edwards2Gary Barker3Alexandre M. Anesio4Department of Ecology, Lake and Glacier Ecology, University of InnsbruckDepartment of Veterinary Population Medicine, University of MinnesotaInstitute of Biological, Environmental and Rural Sciences, Aberystwyth UniversitySchool of Biological Sciences, University of BristolDepartment of Environmental Science, Aarhus UniversityBacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-identical core genomes maintain diversity by possession of numerous flexible gene modules, where homologous genes present in the pan-genome interchange to create new phage variants.https://doi.org/10.1038/s41467-020-18236-8
collection DOAJ
language English
format Article
sources DOAJ
author Christopher M. Bellas
Declan C. Schroeder
Arwyn Edwards
Gary Barker
Alexandre M. Anesio
spellingShingle Christopher M. Bellas
Declan C. Schroeder
Arwyn Edwards
Gary Barker
Alexandre M. Anesio
Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
Nature Communications
author_facet Christopher M. Bellas
Declan C. Schroeder
Arwyn Edwards
Gary Barker
Alexandre M. Anesio
author_sort Christopher M. Bellas
title Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
title_short Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
title_full Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
title_fullStr Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
title_full_unstemmed Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
title_sort flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-09-01
description Bacteriophages and their hosts are involved in a constant evolutionary arms race that should lead to divergence between phage genes over time. Here, the authors recruit metagenomic reads to virus reference genomes and genome fragments in samples from cryoconite holes and show that phages with near-identical core genomes maintain diversity by possession of numerous flexible gene modules, where homologous genes present in the pan-genome interchange to create new phage variants.
url https://doi.org/10.1038/s41467-020-18236-8
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AT declancschroeder flexiblegenesestablishwidespreadbacteriophagepangenomesincryoconiteholeecosystems
AT arwynedwards flexiblegenesestablishwidespreadbacteriophagepangenomesincryoconiteholeecosystems
AT garybarker flexiblegenesestablishwidespreadbacteriophagepangenomesincryoconiteholeecosystems
AT alexandremanesio flexiblegenesestablishwidespreadbacteriophagepangenomesincryoconiteholeecosystems
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