Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function

Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function

Complexin is a small soluble presynaptic protein that interacts with neuronal SNARE proteins in order to regulate synaptic vesicle exocytosis. While the SNARE-binding central helix of complexin is required for both the inhibition of spontaneous fusion and the facilitation of synchronous fusion, the...

Full description

Bibliographic Details
Main Authors: David Snead, Alex L. Lai, Rachel T. Wragg, Daniel A. Parisotto, Trudy F. Ramlall, Jeremy S. Dittman, Jack H. Freed, David Eliezer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
complexin
amphipathic helix
membrane curvature
ESR
NMR
micelles
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00154/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00154/full

Similar Items