Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells

Fine-tuning the metabolic rewiring and adaptation of translational machinery during an epithelial-mesenchymal transition in breast cancer cells

Abstract Background During breast cancer progression, the epithelial to mesenchymal transition has been associated with metastasis and endocrine therapy resistance; however, the underlying mechanisms remain elusive. To gain insight into this process, we studied the transition undergone by MCF7-deriv...

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Bibliographic Details
Main Authors: Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cancer & Metabolism
Subjects:
Breast cancer
EMT
Luminal to basal transition
MKL1/actin signaling pathway
Metabolism adaptation
Translation machinery
Online Access:http://link.springer.com/article/10.1186/s40170-020-00216-7

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http://link.springer.com/article/10.1186/s40170-020-00216-7

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