Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset

Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset

The severity of SARS-CoV-2 infection has been related to uncontrolled inflammatory innate responses and impaired adaptive immune responses mostly due to exhausted T lymphocytes and lymphopenia. In this work we have characterized the nature of the lymphopenia and demonstrate a set of factors that hin...

Full description

Bibliographic Details
Main Authors: Juan Francisco Gutiérrez-Bautista, Antonio Rodriguez-Nicolas, Antonio Rosales-Castillo, Pilar Jiménez, Federico Garrido, Per Anderson, Francisco Ruiz-Cabello, Miguel Ángel López-Ruz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
T-CD8 lymphocytes flow cytometric immunophenotyping
Th lymphocytes
T cell response
severe acute respiratory syndrome coronavirus 2
severe coronavirus disease 2019
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.596553/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.596553/full

Similar Items