The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner
Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferative effects against colorectal cancer cells in cult...
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Elsevier
2017-12-01
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| Series: | Molecular Genetics and Metabolism Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214426917301131 |
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doaj-87ce8acb3465477082e32722e3d860cd2020-11-24T22:25:04ZengElsevierMolecular Genetics and Metabolism Reports2214-42692017-12-0113C424510.1016/j.ymgmr.2017.07.011The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent mannerSarah E. AndersonChristopher E. BartonCardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferative effects against colorectal cancer cells in culture and that the resulting cell death is independent of the p53 tumor suppressor. Our data suggest that convallatoxin may be useful in the treatment of cancers that harbor inactivating mutations in the p53 signaling pathway.http://www.sciencedirect.com/science/article/pii/S2214426917301131CancerApoptosisCell cycleConvallatoxinp53 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sarah E. Anderson Christopher E. Barton |
| spellingShingle |
Sarah E. Anderson Christopher E. Barton The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner Molecular Genetics and Metabolism Reports Cancer Apoptosis Cell cycle Convallatoxin p53 |
| author_facet |
Sarah E. Anderson Christopher E. Barton |
| author_sort |
Sarah E. Anderson |
| title |
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| title_short |
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| title_full |
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| title_fullStr |
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| title_full_unstemmed |
The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| title_sort |
cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner |
| publisher |
Elsevier |
| series |
Molecular Genetics and Metabolism Reports |
| issn |
2214-4269 |
| publishDate |
2017-12-01 |
| description |
Cardiac glycosides are plant-derived molecules that have shown antiproliferative properties against cancer cells, though the mechanism of action is not completely understood. We show that one cardiac glycoside, convallatoxin, presents antiproliferative effects against colorectal cancer cells in culture and that the resulting cell death is independent of the p53 tumor suppressor. Our data suggest that convallatoxin may be useful in the treatment of cancers that harbor inactivating mutations in the p53 signaling pathway. |
| topic |
Cancer Apoptosis Cell cycle Convallatoxin p53 |
| url |
http://www.sciencedirect.com/science/article/pii/S2214426917301131 |
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AT saraheanderson thecardiacglycosideconvallatoxininhibitsthegrowthofcolorectalcancercellsinap53independentmanner AT christopherebarton thecardiacglycosideconvallatoxininhibitsthegrowthofcolorectalcancercellsinap53independentmanner AT saraheanderson cardiacglycosideconvallatoxininhibitsthegrowthofcolorectalcancercellsinap53independentmanner AT christopherebarton cardiacglycosideconvallatoxininhibitsthegrowthofcolorectalcancercellsinap53independentmanner |
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