Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance

Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPARα to activate the NF-κB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance

Abstract Background Alcohol-induced intestinal dysbiosis disrupts and inflammatory responses are essential in the development of alcoholic fatty liver disease (AFLD). Here, we investigated the effects of Fmo5 on changes in enteric microbiome composition in a model of AFLD and dissected the pathogeni...

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Bibliographic Details
Main Authors: Lingjian Kong, Jing Chen, Xiaoli Ji, Qian Qin, Huiyu Yang, Dan Liu, Deliang Li, Meiling Sun
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Alcoholic fatty liver disease
Fmo5
PPARα
NF-κB
Liver injury
Gut microbiota disturbance
Online Access:https://doi.org/10.1186/s13046-020-01782-w

Internet

https://doi.org/10.1186/s13046-020-01782-w

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