Effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy

• Main Author: Guo Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-06-01
• Series: Journal of Hainan Medical University
• Subjects: Diabetic peripheral neuropathy mNGF Neurological function Oxidation stress
• Online Access: http://www.hnykdxxb.com/PDF/201712/13.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of mNGF injection combined with vitamin D and methylamine on neurological function and oxidative stress in patients with diabetic peripheral neuropathy. Methods: 120 patients with diabetic peripheral neuropathy who were treated in our hospital between July 2012 and February 2016 were collected and randomly divided into control group (n=60) and observation group (n=60), control group were treated with vitamin D and methylamine, observation group received mNGF injection combined with vitamin D and methylamine therapy, and both therapies lasted for 8 weeks. Electromyography indexes, neurological function indexes and oxidative stress indexes were compared between two groups of patients before and after treatment. Results: Before treatment, the differences in electromyography indexes, neurological function indexes and oxidative stress indexes were not statistically significant between two groups of patients. After treatment, the MCV and SCV levels of median nerve, ulnar nerve and tibial nerve in observation group were higher than those in control group; serum neurological function indexes BDNF and IGF-1 contents were higher than those in control group while MBP content was lower than that in control group; serum oxidative stress indexes SOD, GSH and T-AOC contents were higher than those in control group while MDA and AOPP contents were lower than those in control group. Conclusion: mNGF injection combined with vitamin D and methylamine can optimize the electromyography and neurological function, and reduce the systemic oxidation stress response in patients with DPN.