Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors
Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to pl...
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.661731/full |
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doaj-87bb4335d1d34c3eb1ececb082acaf3d2021-03-19T06:52:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.661731661731Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant TumorsKang Hu0Qing-Kang Zheng1Rui-Jie Ma2Chao Ma3Zhi-Gang Sun4Nan Zhang5School of Clinical Medicine, Weifang Medical University, Weifang, ChinaSchool of Clinical Medicine, Weifang Medical University, Weifang, ChinaCheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Clinical Medicine, Weifang Medical University, Weifang, ChinaDepartment of Thoracic Surgery, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKrüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains to be determined. The purpose of this article is to provide a comprehensive and systematic review of the important role of KLF6-SV1 in human malignant tumors to provide novel insights for oncotherapy.https://www.frontiersin.org/articles/10.3389/fcell.2021.661731/fullKLF6KLF6-SV1proliferationapoptosisinvasionEMT |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kang Hu Qing-Kang Zheng Rui-Jie Ma Chao Ma Zhi-Gang Sun Nan Zhang |
| spellingShingle |
Kang Hu Qing-Kang Zheng Rui-Jie Ma Chao Ma Zhi-Gang Sun Nan Zhang Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors Frontiers in Cell and Developmental Biology KLF6 KLF6-SV1 proliferation apoptosis invasion EMT |
| author_facet |
Kang Hu Qing-Kang Zheng Rui-Jie Ma Chao Ma Zhi-Gang Sun Nan Zhang |
| author_sort |
Kang Hu |
| title |
Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors |
| title_short |
Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors |
| title_full |
Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors |
| title_fullStr |
Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors |
| title_full_unstemmed |
Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors |
| title_sort |
krüppel-like factor 6 splice variant 1: an oncogenic transcription factor involved in the progression of multiple malignant tumors |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cell and Developmental Biology |
| issn |
2296-634X |
| publishDate |
2021-03-01 |
| description |
Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains to be determined. The purpose of this article is to provide a comprehensive and systematic review of the important role of KLF6-SV1 in human malignant tumors to provide novel insights for oncotherapy. |
| topic |
KLF6 KLF6-SV1 proliferation apoptosis invasion EMT |
| url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.661731/full |
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