Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management

The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This...

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Main Authors:	Irandi Putra Pratomo, Anna Ariane, Aryo Tedjo, Rudi Heryanto, Rafika Indah Paramita
Format:	Article
Language:	English
Published:	Faculty of Medicine Universitas Indonesia 2020-11-01
Series:	Medical Journal of Indonesia
Subjects:	COVID-19 free radicals uric acid xanthine oxidase
Online Access:	http://mji.ui.ac.id/journal/index.php/mji/article/view/4641

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spelling	doaj-87aaa14d678f4d848f3e64914ccf76a32021-02-03T04:22:48ZengFaculty of Medicine Universitas Indonesia Medical Journal of Indonesia0853-17732252-80832020-11-011110.13181/mji.rev.204641Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 managementIrandi Putra Pratomo0Anna Ariane1Aryo Tedjo2Rudi Heryanto3Rafika Indah Paramita4Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, IndonesiaDepartment of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, IndonesiaBioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. http://mji.ui.ac.id/journal/index.php/mji/article/view/4641COVID-19free radicalsuric acidxanthine oxidase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Irandi Putra Pratomo Anna Ariane Aryo Tedjo Rudi Heryanto Rafika Indah Paramita
spellingShingle	Irandi Putra Pratomo Anna Ariane Aryo Tedjo Rudi Heryanto Rafika Indah Paramita Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management Medical Journal of Indonesia COVID-19 free radicals uric acid xanthine oxidase
author_facet	Irandi Putra Pratomo Anna Ariane Aryo Tedjo Rudi Heryanto Rafika Indah Paramita
author_sort	Irandi Putra Pratomo
title	Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management
title_short	Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management
title_full	Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management
title_fullStr	Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management
title_full_unstemmed	Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management
title_sort	xanthine oxidase inhibition in sars-cov-2 infection: the mechanism and potency of allopurinol and febuxostat in covid-19 management
publisher	Faculty of Medicine Universitas Indonesia
series	Medical Journal of Indonesia
issn	0853-1773 2252-8083
publishDate	2020-11-01
description	The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.
topic	COVID-19 free radicals uric acid xanthine oxidase
url	http://mji.ui.ac.id/journal/index.php/mji/article/view/4641
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Xanthine oxidase inhibition in SARS-CoV-2 infection: the mechanism and potency of allopurinol and febuxostat in COVID-19 management

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