Influence of <it>SLCO1B1 </it>and <it>CYP2C8 </it>gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Influence of <it>SLCO1B1 </it>and <it>CYP2C8 </it>gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

<p>Abstract</p> <p>Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effects of polymorphisms in the <it>SLCO1B1 </it>...

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Bibliographic Details
Main Authors: Aquilante Christina L, Bushman Lane R, Knutsen Shannon D, Burt Lauren E, Rome Lucille Capo, Kosmiski Lisa A
Format: Article
Language:English
Published: BMC 2008-09-01
Series:Human Genomics
Subjects:
rosiglitazone
thiazolidinedione
pharmacokinetic
pharmacogenetic
CYP2C8
SLCO1B1
Online Access:http://www.humgenomics.com/content/3/1/7

Internet

http://www.humgenomics.com/content/3/1/7

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