Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

The application of nanofibres formed from monomers of bacterial type IV pili in vitrohas proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet.

Bibliographic Details
Main Authors:	Tom Guterman, Micha Kornreich, Avigail Stern, Lihi Adler-Abramovich, Danny Porath, Roy Beck, Linda J. W. Shimon, Ehud Gazit
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13482

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spelling	doaj-878c88710f364c8eb3dc72ffe6680c882021-05-11T11:01:59ZengNature Publishing GroupNature Communications2041-17232016-11-017111010.1038/ncomms13482Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptidesTom Guterman0Micha Kornreich1Avigail Stern2Lihi Adler-Abramovich3Danny Porath4Roy Beck5Linda J. W. Shimon6Ehud Gazit7Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv UniversityInstitute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra CampusDepartment of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv UniversityInstitute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra CampusThe Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv UniversityDepartment of Chemical Research Support, Weizmann Institute of ScienceDepartment of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv UniversityThe application of nanofibres formed from monomers of bacterial type IV pili in vitrohas proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet.https://doi.org/10.1038/ncomms13482
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tom Guterman Micha Kornreich Avigail Stern Lihi Adler-Abramovich Danny Porath Roy Beck Linda J. W. Shimon Ehud Gazit
spellingShingle	Tom Guterman Micha Kornreich Avigail Stern Lihi Adler-Abramovich Danny Porath Roy Beck Linda J. W. Shimon Ehud Gazit Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides Nature Communications
author_facet	Tom Guterman Micha Kornreich Avigail Stern Lihi Adler-Abramovich Danny Porath Roy Beck Linda J. W. Shimon Ehud Gazit
author_sort	Tom Guterman
title	Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
title_short	Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
title_full	Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
title_fullStr	Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
title_full_unstemmed	Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
title_sort	formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	The application of nanofibres formed from monomers of bacterial type IV pili in vitrohas proven to be complex. Here, the authors have overcome this limitation by using a reductionist approach to design a self-assembling pilin-based 20-mer peptide capable of forming a supramolecular beta sheet.
url	https://doi.org/10.1038/ncomms13482
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Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

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