Sural sensory nerve action potential: A study in healthy Indian subjects
Background: The sural sensory nerve action potential (SNAP) is an important electrodiagnostic study for suspected peripheral neuropathies. Incorrect technique and unavailability of reference data can lead to erroneous conclusions. Objectives: To establish reference data for sural SNAP in age-stratif...
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doaj-878c32516afb406792e56cbb50b0c8062020-11-25T01:34:33ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492016-01-0119331231710.4103/0972-2327.186786Sural sensory nerve action potential: A study in healthy Indian subjectsAarthika SreenivasanKhushnuma A MansukhaniAlika SharmaLajita BalakrishnanBackground: The sural sensory nerve action potential (SNAP) is an important electrodiagnostic study for suspected peripheral neuropathies. Incorrect technique and unavailability of reference data can lead to erroneous conclusions. Objectives: To establish reference data for sural SNAP in age-stratified healthy subjects at three sites of stimulation. Materials and Methods: A prospective study was conducted in 146 nerves from healthy subjects aged between 18 years and 90 years, stratified into six age groups (a = 18-30 years, b = 31-40 years, c = 41-50 years, d = 51-60 years, e = 61-70 years, and f >71 years). Sural SNAP was recorded antidromically, stimulating at three sites at distances of 14 cm, 12 cm, and 10 cm from the recording electrode. Mean - 2 standard deviation (SD) of the transformed data was used to generate reference values for amplitudes. Analysis of variance (ANOVA) test was used for inter-group and between three sites comparisons of amplitudes. Results: The lower limits of amplitude at 14 cm were 12.4 μV, 10.4 μV, 6.5 μV, 5.3 μV, 2.9 μV, and 1.9 μV; at 12 cm were 13.5 μV, 13.6 μV, 8.5 μV, 7.8 μV, 3.5 μV, and 2.8 μV; and at 10 cm were 16.3 μV, 16.3 μV, 11.1 μV, 10.0 μV, 4.8 μV, and 3.7 μV for groups a, b, c, d, e, and f, respectively. A statistically significant difference in amplitudes was noted from the three different sites of stimulation (P < 0.001). The amplitude differed significantly above the age of 60 years (P < 0.01) but not between groups e and f (P > 0.05). Conclusion: This study provides reference data for sural SNAP in Indian population at three different sites of stimulation along the calf in six age groups. It also shows significant variation in amplitude from the three different sites of stimulation.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=312;epage=317;aulast=SreenivasanAgeamplitudeIndianreference valuesstimulation sitesural |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aarthika Sreenivasan Khushnuma A Mansukhani Alika Sharma Lajita Balakrishnan |
spellingShingle |
Aarthika Sreenivasan Khushnuma A Mansukhani Alika Sharma Lajita Balakrishnan Sural sensory nerve action potential: A study in healthy Indian subjects Annals of Indian Academy of Neurology Age amplitude Indian reference values stimulation site sural |
author_facet |
Aarthika Sreenivasan Khushnuma A Mansukhani Alika Sharma Lajita Balakrishnan |
author_sort |
Aarthika Sreenivasan |
title |
Sural sensory nerve action potential: A study in healthy Indian subjects |
title_short |
Sural sensory nerve action potential: A study in healthy Indian subjects |
title_full |
Sural sensory nerve action potential: A study in healthy Indian subjects |
title_fullStr |
Sural sensory nerve action potential: A study in healthy Indian subjects |
title_full_unstemmed |
Sural sensory nerve action potential: A study in healthy Indian subjects |
title_sort |
sural sensory nerve action potential: a study in healthy indian subjects |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Indian Academy of Neurology |
issn |
0972-2327 1998-3549 |
publishDate |
2016-01-01 |
description |
Background: The sural sensory nerve action potential (SNAP) is an important electrodiagnostic study for suspected peripheral neuropathies. Incorrect technique and unavailability of reference data can lead to erroneous conclusions. Objectives: To establish reference data for sural SNAP in age-stratified healthy subjects at three sites of stimulation. Materials and Methods: A prospective study was conducted in 146 nerves from healthy subjects aged between 18 years and 90 years, stratified into six age groups (a = 18-30 years, b = 31-40 years, c = 41-50 years, d = 51-60 years, e = 61-70 years, and f >71 years). Sural SNAP was recorded antidromically, stimulating at three sites at distances of 14 cm, 12 cm, and 10 cm from the recording electrode. Mean - 2 standard deviation (SD) of the transformed data was used to generate reference values for amplitudes. Analysis of variance (ANOVA) test was used for inter-group and between three sites comparisons of amplitudes. Results: The lower limits of amplitude at 14 cm were 12.4 μV, 10.4 μV, 6.5 μV, 5.3 μV, 2.9 μV, and 1.9 μV; at 12 cm were 13.5 μV, 13.6 μV, 8.5 μV, 7.8 μV, 3.5 μV, and 2.8 μV; and at 10 cm were 16.3 μV, 16.3 μV, 11.1 μV, 10.0 μV, 4.8 μV, and 3.7 μV for groups a, b, c, d, e, and f, respectively. A statistically significant difference in amplitudes was noted from the three different sites of stimulation (P < 0.001). The amplitude differed significantly above the age of 60 years (P < 0.01) but not between groups e and f (P > 0.05). Conclusion: This study provides reference data for sural SNAP in Indian population at three different sites of stimulation along the calf in six age groups. It also shows significant variation in amplitude from the three different sites of stimulation. |
topic |
Age amplitude Indian reference values stimulation site sural |
url |
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=3;spage=312;epage=317;aulast=Sreenivasan |
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