To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites
Recent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamin...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-04-01
|
| Series: | Green Processing and Synthesis |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/gps-2016-0125 |
| id |
doaj-8789f0590491446bbad15d421222be1d |
|---|---|
| record_format |
Article |
| spelling |
doaj-8789f0590491446bbad15d421222be1d2021-10-02T19:16:48ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502017-04-016219720110.1515/gps-2016-0125To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphitesKeglevich György0Rádai Zita1Kiss Nóra Zsuzsa2Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryRecent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamine as the catalyst and a minimum quantity of acetone as the solvent, giving the products in a pure form after a reflux of 5–120 min following the addition of some n-pentane and crystallization on cooling.https://doi.org/10.1515/gps-2016-0125α-hydroxyphosphonatesgreen synthesisgreen work-uppudovik reaction |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Keglevich György Rádai Zita Kiss Nóra Zsuzsa |
| spellingShingle |
Keglevich György Rádai Zita Kiss Nóra Zsuzsa To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites Green Processing and Synthesis α-hydroxyphosphonates green synthesis green work-up pudovik reaction |
| author_facet |
Keglevich György Rádai Zita Kiss Nóra Zsuzsa |
| author_sort |
Keglevich György |
| title |
To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| title_short |
To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| title_full |
To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| title_fullStr |
To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| title_full_unstemmed |
To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| title_sort |
to date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites |
| publisher |
De Gruyter |
| series |
Green Processing and Synthesis |
| issn |
2191-9542 2191-9550 |
| publishDate |
2017-04-01 |
| description |
Recent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamine as the catalyst and a minimum quantity of acetone as the solvent, giving the products in a pure form after a reflux of 5–120 min following the addition of some n-pentane and crystallization on cooling. |
| topic |
α-hydroxyphosphonates green synthesis green work-up pudovik reaction |
| url |
https://doi.org/10.1515/gps-2016-0125 |
| work_keys_str_mv |
AT keglevichgyorgy todatethegreenestmethodforthepreparationofahydroxyphosphonatesfromsubstitutedbenzaldehydesanddialkylphosphites AT radaizita todatethegreenestmethodforthepreparationofahydroxyphosphonatesfromsubstitutedbenzaldehydesanddialkylphosphites AT kissnorazsuzsa todatethegreenestmethodforthepreparationofahydroxyphosphonatesfromsubstitutedbenzaldehydesanddialkylphosphites |
| _version_ |
1716847438382235648 |