To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites
Recent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-04-01
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| Series: | Green Processing and Synthesis |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/gps-2016-0125 |
| Summary: | Recent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamine as the catalyst and a minimum quantity of acetone as the solvent, giving the products in a pure form after a reflux of 5–120 min following the addition of some n-pentane and crystallization on cooling. |
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| ISSN: | 2191-9542 2191-9550 |