Significance of sphingosine kinase 1 expression in feline mammary tumors

Significance of sphingosine kinase 1 expression in feline mammary tumors

Abstract Background Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate. There is growing evidence that SPHK1 activation promotes oncogenic transformation, tumor growth, chemotherapy resistance, and metastatic spr...

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Bibliographic Details
Main Authors: Yi-Chih Chang, Hsiao-Li Chuang, Ji-Hang Yin, Jiunn-Wang Liao, Ter-Hsin Chen, Yu-Chih Wang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Veterinary Research
Subjects:
Feline mammary tumor
SPHK1 - comparative oncology
Online Access:http://link.springer.com/article/10.1186/s12917-019-1883-z

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