Tracking tumor evolution via prostate-specific antigen: an individual post-operative study

<p>Abstract</p> <p>Background</p> <p>The progress of the prostate-specific antigen (PSA) level after radical prostatectomy is observed for a patient in order to extract information about the mode of tumor cell growth. Although PSA values are determined routinely to find...

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Main Authors: Erzan Ayşe, Erbudak Mehmet
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Theoretical Biology and Medical Modelling
Online Access:http://www.tbiomed.com/content/7/1/30
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spelling doaj-87805f45d3b244718a54dcdc6869a6ac2020-11-24T21:19:07ZengBMCTheoretical Biology and Medical Modelling1742-46822010-07-01713010.1186/1742-4682-7-30Tracking tumor evolution via prostate-specific antigen: an individual post-operative studyErzan AyşeErbudak Mehmet<p>Abstract</p> <p>Background</p> <p>The progress of the prostate-specific antigen (PSA) level after radical prostatectomy is observed for a patient in order to extract information about the mode of tumor cell growth. Although PSA values are determined routinely to find the doubling time of the prostate marker, to our knowledge, this analysis is the first in the literature.</p> <p>Results</p> <p>The prostate tumor marker values were determined regularly after the surgery and plotted on a logarithmic scale against time. An initial rapid-growth mode changed to a slower power-law regime within two years of surgery. Our analysis associates this observation with a transition in the growth mode from unrestricted growth of dispersed cells to their clumping into macroscopic structures.</p> <p>Conclusions</p> <p>Such studies may help determine the appropriate time window for postoperative therapies in order to increase the life expectancy of the patient.</p> http://www.tbiomed.com/content/7/1/30
collection DOAJ
language English
format Article
sources DOAJ
author Erzan Ayşe
Erbudak Mehmet
spellingShingle Erzan Ayşe
Erbudak Mehmet
Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
Theoretical Biology and Medical Modelling
author_facet Erzan Ayşe
Erbudak Mehmet
author_sort Erzan Ayşe
title Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
title_short Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
title_full Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
title_fullStr Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
title_full_unstemmed Tracking tumor evolution via prostate-specific antigen: an individual post-operative study
title_sort tracking tumor evolution via prostate-specific antigen: an individual post-operative study
publisher BMC
series Theoretical Biology and Medical Modelling
issn 1742-4682
publishDate 2010-07-01
description <p>Abstract</p> <p>Background</p> <p>The progress of the prostate-specific antigen (PSA) level after radical prostatectomy is observed for a patient in order to extract information about the mode of tumor cell growth. Although PSA values are determined routinely to find the doubling time of the prostate marker, to our knowledge, this analysis is the first in the literature.</p> <p>Results</p> <p>The prostate tumor marker values were determined regularly after the surgery and plotted on a logarithmic scale against time. An initial rapid-growth mode changed to a slower power-law regime within two years of surgery. Our analysis associates this observation with a transition in the growth mode from unrestricted growth of dispersed cells to their clumping into macroscopic structures.</p> <p>Conclusions</p> <p>Such studies may help determine the appropriate time window for postoperative therapies in order to increase the life expectancy of the patient.</p>
url http://www.tbiomed.com/content/7/1/30
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AT erbudakmehmet trackingtumorevolutionviaprostatespecificantigenanindividualpostoperativestudy
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