Transient Response of Olaparib on Pulmonary Artery Sarcoma Harboring Multiple Homologous Recombinant Repair Gene Alterations

Transient Response of Olaparib on Pulmonary Artery Sarcoma Harboring Multiple Homologous Recombinant Repair Gene Alterations

Primary pulmonary artery sarcoma (PPAS) is a rare malignancy arising from mesenchymal pulmonary artery cells and mimics pulmonary embolism. Palliative chemotherapy such as anthracycline- or ifosfamide-based regimens and targeted therapy are the only options. However, the evidence of clinically benef...

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Bibliographic Details
Main Authors: Chiao-En Wu, Ca Tung Ng, Kien Thiam Tan
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Personalized Medicine
Subjects:
PARP inhibitor
olaparib
next-generation sequencing (NGS)
comprehensive genetic profiling (CGP)
primary pulmonary artery sarcoma (PPAS)
homologous recombination repair (HRR)
Online Access:https://www.mdpi.com/2075-4426/11/5/357

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